Principal Scientist - In Vivo Pharmacology Lead-Seattle Metro Area

Company: Pfizer, S.A. de C.V
Location: Bothell
Posted on: November 2, 2024

Job Description:

We're in relentless pursuit of breakthroughs that change patients' lives. We innovate every day to make the world a healthier place.To fully realize Pfizer's purpose - Breakthroughs that change patients' lives - we have established a clear set of expectations regarding "what" we need to achieve for patients and "how" we will go about achieving those goals.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.POSITION SUMMARYThis position is based at our Bothell, WA site which is approximately 15 miles from the downtown Seattle area.You will participate in pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. You will be responsible for working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision-making. You will also be a key stakeholder/ contributor to the In Vivo Committee, responsible for vetting study designs and strategies and ensuring timely completion of research project objectives. You will directly supervise laboratory staff that make up an in vivo team responsible for study execution and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in in vivo pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization and efficient drug discovery.POSITION RESPONSIBILITIES

• Collaborate across project teams to establish in vivo strategy and study plans for drug discovery projects.
• Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
• Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.
• Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.
• Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
• Supervise and guide a small team of scientists.
• Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
• Ensure team members comply with all regulatory requirements and internal policies.
• Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary.
• Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment.
• Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings.
• Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.QUALIFICATIONSMust-Have
  • Ph.D. in Cancer Biology, Immunology, Genetics or a related discipline and a minimum 5 years industry experience including technical and scientific experience in drug discovery and preclinical development OR
  • MS in Cancer Biology, Immunology, Genetics or a related discipline and a minimum 10 years industry experience including technical and scientific experience in drug discovery and preclinical development OR
  • BS in Cancer Biology, Immunology, Genetics or a related discipline and a minimum 13 years industry experience including technical and scientific experience in drug discovery and preclinical development.
  • Experience in collaborative research in Oncology drug discovery programs.
  • Experience with animal models of human cancers.
  • Hands on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).
  • Experience supervising a small team of Scientists.
  • Excellent written and oral communication and presentation skills.
  • Proficiency with all common office and scientific software.Preferred
    • Strong track record of publications or evidence of equivalent achievements in industry.
    • Experience with GEMM and humanized models.
    • Experience with Antibody Drug Conjugates (ADC).PHYSICAL/MENTAL REQUIREMENTSLifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTSMust be willing to work after hours as needed to ensure study integrity.Why Patients Need YouPfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
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Keywords: Pfizer, S.A. de C.V, Redmond , Principal Scientist - In Vivo Pharmacology Lead-Seattle Metro Area, Other , Bothell, Washington